The cost of medication non-compliance to the healthcare system is estimated to be between $100 and $300 billion annually in the United States. This represents 3-10% of total healthcare costs. Medication non-compliance for chronic conditions such as diabetes and hypertension can be very costly, as these conditions can lead to severe complications if they are not adequately managed.
There are many reasons why patients may be noncompliant when taking medications. Some of the most common reasons include:
- Cost: Medications can be expensive, and some patients may not be able to afford them.
- Side effects: Some medications have side effects that can be unpleasant or even dangerous. This can lead patients to stop taking the medication or not taking it as prescribed.
- Forgetfulness: It can be easy to forget to take medications, especially if they are not taken regularly.
- Lack of understanding: Patients may not understand why they take medication or how it works. This can lead them to believe they do not need to take the medication or can take it less often.
- Poor communication with healthcare providers: Patients may not have a good relationship with their healthcare providers. This can make it difficult for them to ask questions or to get the information they need to take their medications correctly.
- Mental health conditions: Patients with mental health conditions, such as depression or anxiety, may be more likely to be noncompliant with their medications.
- Cultural factors: Cultural beliefs or practices may also influence a patient’s decision to take or not take medication.
It is important to identify the reasons why a patient is noncompliant so that the healthcare provider can address them. There are a number of things that can be done to improve medication adherence, such as:
- Providing financial assistance: If cost is a barrier, the healthcare provider may be able to help the patient find financial assistance to pay for the medication.
- Managing side effects: If side effects are a problem, the healthcare provider may be able to adjust the dosage or switch to a different medication.
- Reminding patients to take their medication: There are several ways to remind patients to take their medication, such as setting alarms, using medication reminder apps, or having a family member or friend help.

- Providing education: The healthcare provider can provide the patient with education about the medication, including why it is being prescribed, how it works, and what side effects to expect.
- Building a strong relationship with the patient: The healthcare provider can build a strong relationship with the patient by listening to their concerns, being understanding, and providing support.
Pharmace companies can play a role in increasing medication compliance by:
- Diverting some of the consumer marketing budgets to adherence efforts. This could involve funding educational programs, providing patient support services, or developing innovative adherence tools.
- Improving patient education and support throughout treatment. This includes providing clear and concise information about the medication, its side effects, and the importance of taking it as prescribed. It also means providing patients with the support they need to overcome barriers to adherence, such as financial hardship or transportation challenges.
- Leveraging technology. There are several technological tools that can help improve medication compliance, such as electronic pillboxes, medication reminders, and remote monitoring programs.
- Working with healthcare providers. Pharmaceutical companies can work with healthcare providers to educate them about the importance of medication adherence and to develop strategies for improving it.
In addition to these general strategies, pharma companies can address specific barriers to adherence that are relevant to their products. For example, if a medication has a complex dosage schedule, the company could develop a simplified version or provide patient education materials that make it easier to understand.

By taking these steps, pharma companies can help improve medication compliance and patient health outcomes.
Here are some additional specific strategies that pharmaceutical companies can use to increase medication compliance:
- Personalize the patient experience. By understanding the individual patient’s needs and preferences, pharmaceutical companies can develop adherence programs that are more likely to be successful. This could involve giving patients choices in dosage form, delivery method, or even the color of the medication.
- Use data-driven insights. By collecting and analyzing data about patient adherence, pharmaceutical companies can identify patterns and trends that can be used to improve their adherence programs. For example, they can use data to identify patients who are at risk of non-adherence and target them with interventions that are more likely to be effective.
- Partner with other stakeholders. Pharmaceutical companies can work with other stakeholders in the healthcare system, such as healthcare providers, insurers, and patient advocacy groups, to develop and implement adherence programs. These stakeholders can create a more cohesive and practical approach to improving medication compliance by working together.
Improving medication compliance is a complex challenge, but it is one that pharmaceutical companies can play a significant role in addressing. By taking the steps outlined above, pharmaceutical companies can help improve patients’ health outcomes and reduce the financial burden of non-adherence.