Does Novo Nordisk think people are that stupid?

FILE PHOTO: A 0.25 mg injection pen of Novo Nordisk's weight-loss drug Wegovy is shown in this photo illustration in Oslo, Norway, September 1, 2023. REUTERS/Victoria Klesty/Illustration/File Photo

The headlines around Wegovy are all over the Internet, saying Wegovy was shown to reduce those people’s risk of another cardiovascular event by 20%. However, if you read the comments from informed people, they note the correlation between weight loss, in general, and lower CV events. Novo loves the fact that the media is doing their DTC for them.

The Correlation Between Weight Loss and Reduced Cardiovascular Events: Unveiling the Vital Connection

The connection between weight loss and the reduction in cardiovascular events has long been a subject of extensive research, shedding light on the intricate relationship between body weight and heart health.

The Weighty Impact on Cardiovascular Health

Cardiovascular diseases, encompassing conditions like heart attacks and strokes, continue to be a leading cause of mortality worldwide. They are often rooted in risk factors such as high blood pressure, elevated cholesterol levels, and diabetes. Weight, specifically excess body weight or obesity, is intricately linked to the development and progression of these risk factors.

Unraveling the Connection

Scientific studies consistently highlight the profound impact of weight loss on cardiovascular health. Shedding even a modest amount of weight can significantly reduce the risk factors associated with heart disease. Decreased body weight often improves blood pressure, cholesterol levels, insulin sensitivity, and inflammation – all crucial elements contributing to a healthier heart.

Mechanisms at Play

Weight loss triggers positive physiological changes that directly benefit cardiovascular health. It reduces the workload on the heart, decreases the accumulation of fatty deposits in arteries, and improves the function of the endothelium, the inner lining of blood vessels. These changes collectively contribute to a decreased risk of heart-related complications.

Beyond the Scale: The Role of Lifestyle Modifications

However, the correlation between weight loss and cardiovascular health isn’t solely reliant on the numbers on a scale. It’s also profoundly entwined with lifestyle modifications. Adopting healthier eating habits, regular physical activity, and managing stress are pivotal in sustaining weight loss and reaping cardiovascular benefits.

The Human Canvas of Evidence

In the clinical realm, numerous studies have showcased the direct impact of weight loss interventions on cardiovascular outcomes. For instance, research such as the Look AHEAD study revealed that significant weight loss among individuals with obesity reduced the risk of heart disease and improved overall cardiovascular health. Moreover, weight loss has been linked to a lower incidence of atrial fibrillation, heart failure, and stroke.

The Holistic Approach: Combating Cardiovascular Events

Recognizing the symbiotic relationship between weight loss and heart health underlines the importance of a holistic approach to combat cardiovascular events. Implementing comprehensive lifestyle changes, including a balanced diet, regular exercise, stress management, and adequate sleep, can lead to weight reduction and significantly mitigate cardiovascular disease risk.

A Continuum of Health

While the correlation between weight loss and reduced cardiovascular events is indisputable, viewing weight as just one aspect of overall health is vital. A focus on achieving a healthy weight should be intertwined with an emphasis on overall well-being, encompassing mental health, quality nutrition, physical activity, and regular medical check-ups.


The connection between weight loss and decreased cardiovascular events is a theoretical correlation and a well-established and evidence-backed relationship. Weight loss, primarily through healthy lifestyle changes, is a cornerstone in preventing and managing cardiovascular diseases. Embracing a holistic approach to health, where weight loss is part of a broader spectrum of well-being, can significantly reduce the burden of heart-related complications and lead individuals toward a healthier, heartier life.

What we still don’t know

Understanding their long-term effects is crucial with new medications, especially those related to diets or weight management. These drugs often undergo rigorous testing before approval, but long-term effects might not be fully understood until they’ve been in use for a while. It’s vital for ongoing research and monitoring to comprehend the potential consequences of extended usage.

As more people turn to blockbuster diabetes and obesity drugs such as Wegovy, Ozempic, and Mounjaro, some are grappling with an unwelcome trade-off: how to balance uncomfortable, sometimes painful, side effects with the benefits of reduced food cravings and the loss of substantial weight.

People who take popular drugs for weight loss, such as Ozempic or Wegovy, may be at an increased risk of severe stomach problems, research in the Journal of the American Medical Association finds.

Healthy eating habits, regular exercise, and lifestyle changes remain the cornerstones of effective, sustainable weight management. Considering its potential benefits and risks, it’s essential to consult healthcare professionals before starting any new supplement or medication, but people want instant gratification.

The media should do their due diligence before promoting a drug that is both costly and may have severe side effects.